The Cochrane Collaboration recently published a review evaluating the effectiveness of systemic acyclovir for primary herpetic gingivostomatitis.
Preparation of the review involved searching selected databases for randomized controlled trials which compared acyclovir to placebo in children and young adults under 25 years of age with a diagnosis of primary herpetic gingivostomatitis with or without herpes labialis. Selected databases included: Cochrane Oral Health Group’s Trials Register, Cochrane Central Register of Controlled Trials, MEDLINE, and EMBASE.
The authors concluded that there is some weak evidence that acyclovir can be an effective treatment in decreasing some of the symptoms caused by primary herpetic gingivostomatitis.
The full review may be read here.
Citations for additional articles on this topic, as indexed in PubMed, may be found here.